Serious side effects from GLP-1 medications are rare, but some symptoms may require urgent medical attention.
This article explains which symptoms may be signs of a more serious reaction and when to seek emergency care, or when to call 911.
Seek Immediate Medical Attention If You Experience
Please seek urgent medical care or go to the emergency room if you experience:
Severe or persistent abdominal pain
Pain that spreads to your back
Persistent vomiting or inability to keep fluids down
Yellowing of the skin or eyes (jaundice)
Severe dehydration symptoms
Difficulty breathing
Swelling of the face, lips, tongue, or throat
Signs of a severe allergic reaction
These symptoms may require immediate medical evaluation.
Rare but Serious Conditions
Rare complications associated with GLP-1 medications may include:
Pancreatitis
Gallbladder problems
Severe dehydration or kidney injury
Severe allergic reactions
Gastroparesis (severely delayed stomach emptying)
Bowel obstruction
Vision changes in patients with diabetes
Severe low blood sugar when combined with certain diabetes medications
These reactions are uncommon, but it is important to recognize symptoms early.
Possible Warning Signs to Watch For
Please contact your provider promptly if you notice:
Severe or worsening stomach pain
Ongoing vomiting or severe bloating
Difficulty swallowing
Lumps or swelling in the neck
Significant vision changes
Severe weakness or dehydration
Mood changes or unusual behavioral changes
Important Safety Information
GLP-1 medications may not be appropriate for some patients with certain medical histories, including:
Personal or family history of medullary thyroid carcinoma (MTC)
Multiple endocrine neoplasia syndrome type 2 (MEN 2)
Prior severe allergic reactions to GLP-1 medications
Always discuss your medical history with your licensed provider before starting treatment.
Related Support Articles
Note: For information about mild or expected symptoms, refer to:
Common GLP-1 Side Effects & When to Contact Your Provider
Foods and Eating Tips to Help Reduce GLP-1 Nausea
When to Message Us About a Symptom
Need Additional Help?
Serious side effects from GLP-1 medications are uncommon, but severe or rapidly worsening symptoms should never be ignored. If you are unsure whether your symptoms may require urgent care, please contact a medical professional immediately.
If you have any more questions, you can contact the Mevo Health support team through live chat.