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How Does Tirzepatide Work?

How dual GIP/GLP-1 medication works.

Maya avatar
Written by Maya
Updated over 2 weeks ago

Tirzepatide is one of the most effective modern medications for weight loss.
It works by targeting two natural appetite-regulating hormones in your body at the same time:

  • GLP-1 (helps you feel full and slows digestion)

  • GIP (helps control cravings and improves how your body uses food for energy)

Because it activates both of these pathways, tirzepatide is often more powerful and faster-acting than GLP-1 alone.

What this means for you

Patients usually report:

  • Feeling full much sooner during meals

  • Dramatically reduced cravings

  • Less “food noise” or constant thinking about food

  • More stable energy levels

  • Better blood sugar control

  • A sense of being “back in control” of hunger again

Weight loss expectations

Most patients lose 15–22% of their total body weight over 6–12 months when they:

  • Take the medication consistently

  • Slowly increase doses as recommended

  • Follow the lifestyle guidance provided

  • Stay hydrated and eat smaller meals

Some patients lose even more, depending on metabolism, age, and starting weight.

How you take it

You take tirzepatide once a week using a tiny, very thin needle.
Most people say the injection feels like a quick pinch or almost nothing at all.

Your Mevo Health care team will guide you step-by-step, including:

  • where to inject

  • how much to take each week

  • when to increase your dose

  • how to manage any mild nausea

We’re here to support you through the entire journey.

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